1-O-Hexadecyl-2-O-acetyl-sn-glycero-3-phosphocholine

1-O-Hexadecyl-2-O-acetyl-sn-glycero-3-phosphocholine

Product Number: 4006552

CAS Number: 74389-68-7

CHF 169.10 – CHF 1,686.30

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Product Description

Accelerated cognitive decline in Alzheimer’s patients is associated with accumulation of choline-containing phospholipids. One of them, C16-PAF, is specifically elevated in brains of Alzheimer’s patients. Enhanced exposure to this platelet-activating factor ultimately leads to neuronal death.

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Amyloid Beta Peptides & Alzheimer's Disease

Pipecolic acid-catalyzed direct asymmetric mannich reactions.

P.H.Y.Cheong et al., Org. Lett., 8, 811 (2006)

Amyloid-beta42 signals tau hyperphosphorylation and compromises neuronal viability by disrupting alkylacylglycerophosphocholine metabolism.

S.D.Ryan et al., Proc. Natl. Acad. Sci. USA, 106, 20936 (2009)

Srf1 is a novel regulator of phospholipase D activity and is essential to buffer the toxic effects of C16:0 platelet activating factor.

M.A.Kennedy et al., PLoS Genet., 7, e1001299 (2011)

PAF produced by human breast cancer cells promotes migration and proliferation of tumor cells and neo-angiogenesis.

B.Bussolati et al., Am. J. Pathol., 157, 1713 (2000)

Molecular weight: 523.69

Chemical Formula: C₂₆H₅₄NO₇P

Storage Temperature: < -15°C

Synonyms: PAF (C₁₆)

Old Product Number: O-1270

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