Cyclo(-His-Pro)

Cyclo(-His-Pro)

Product Number: 4003655

CAS Number: 53109-32-3

€ 88.80 – € 356.30

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Product Description

Cyclo(His-Pro), a diketopiperazine showing various biological effects in the CNS, as well as endocrine effects, has been isolated from several mammalian tissues. In some cases, it has been identified as a degradation product of thyrotropin-releasing hormone (TRH). In the presence of zinc ions, cyclo(His-Pro) showed hypoglycemic effects and induced body weight reduction in rats.

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Diabetes Peptides

X-Prolyl dipeptidyl-aminopeptidase activity, with X-proline p-nitroanilides as substrates, in normal and pathological human sera.

M.Hino et al., Clin. Chem., 22, 1256 (1976)

Identification of the endogenous key substrates of the human organic cation transporter OCT2 and their implication in function of dopaminergic neurons.

D.Taubert et al., PLoS One, 2, e385 (2007)

Body weight reduction in rats by oral treatment with zinc plus cyclo-(His-Pro).

M.K.Song et al., Br. J. Pharmacol., 158, 442 (2009)

Peptides related to thyrotrophin-releasing hormone are degraded in seminal plasma by an enzyme similar to prolyl endopeptidase.

R.J.Siviter and S.M.Cockle, J. Endocrinol., 144, 61 (1995)

Differential gene expression in pancreatic tissues of streptozocin-induced diabetic rats and genetically-diabetic mice in response to hypoglycemic dipeptide cyclo (His-Pro) treatment.

S.Choi et al., Mol. Biol. Rep., 39, 881 (2012)

Molecular weight: 234.26

Chemical Formula: C₁₁H₁₄N₄O₂

Storage Temperature: < -15°C

Source: Synthetic

Old Product Number: G-1745

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