Z-Phe-Arg-AMC · HCl

Z-Phe-Arg-AMC · HCl

Product Number: 4003379

CAS Number: 70382-26-2

€ 133.80 – € 535

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Product Description

A fluorogenic substrate for cruzipain, plasma kallikrein and soybean trypsin-like enzyme. Z-FR-AMC was also found to be an excellent substrate for the fluorometric assay of cathepsin B, cathepsin K, and cathepsin L as well as papain. Z-FR-AMC-is also an often-used substrate for falcipain I and II. The free peptide has the CAS number 65147-22-0.

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Guinea pig lung tryptase. Localisation to mast cells and characterisation of the partially purified enzyme.

A.R.McEuen et al., Biochem. Pharmacol., 52, 331 (1996)

Design and optimization of a series of novel 2-cyano-pyrimidines as cathepsin K inhibitors.

Z.Rankovic et al., Bioorg. Med. Chem. Lett., 20, 1524 (2010)

Dioxo-triazines as a novel series of cathepsin K inhibitors.

Z.Rankovic et al., Bioorg. Med. Chem. Lett., 20, 1488 (2010)

Fluid phase activation of Hageman factor (factor XII) in citrated human plasma by bromelain: an application to the indirect enzymatic assay for Hageman factor.

S.Oh-ishi, Thromb. Res., 27, 619 (1982)

Human liver cathepsin L.

R.W.Mason et al., Biochem. J., 226, 233 (1985)

Enzymatic properties of human Hageman factor fragment with plasma prekallikrein and synthetic substrates.

Y.Hojima et al., Thromb. Res., 18, 417 (1980)

Inhibition of a cathepsin L-like cysteine protease by a chimeric propeptide-derived inhibitor.

E.Godat et al., Biochemistry, 44, 10486 (2005)

Inhibition of cathepsin B by its propeptide: use of overlapping peptides to identify a critical segment.

J.R.Chagas et al., FEBS Lett., 392, 233 (1996)

Characterization of native and recombinant falcipain-2, a principal trophozoite cysteine protease and essential hemoglobinase of Plasmodium falciparum.

B.R.Shenai et al., J. Biol. Chem., 275, 29000 (2000)

Human plasma kallikrein. A rapid purification method with high yield.

H.Nagase and A.J.Barrett, Biochem. J., 193, 187 (1981)

Rapid interaction of cathepsin L by Z-Phe-PheCHN12 and Z-Phe-AlaCHN2.

H.Kirschke and E.Shaw, Biochem. Biophys. Res. Commun., 101, 454 (1981)

Molecular weight: 649.15

Sum Formula: C₃₃H₃₆N₆O₆ · HCl

Storage Temperature: < -15°C

One Letter code: Z-FR-AMC · HCl

Source: Synthetic

Old Product Number: I-1160

Substrates
Cathepsin B
Cathepsin L
Papain
Plasma Kallikrein
Vignain
Cruzipain
Chymopapain
Cathepsin K
Falcipain II
Falcipain I

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