Suc-Ala-Ala-Pro-Phe-pNA

Suc-Ala-Ala-Pro-Phe-pNA

Product Number: 4002299

CAS Number: 70967-97-4

CHF 112.40 – CHF 1,012.20

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Product Description

A readily soluble, specific and sensitive substrate for chymotrypsin and human pancreatic elastase. It is also hydrolyzed by cathepsin G and chymase. Furthermore it is the standard substrate for FK-506 binding proteins (FKBPs, also called macrophilins) and cyclophilins, which belong to the group of peptidyl prolyl cis-trans isomerases (PPIases). Thus, Suc-AAPF-pNA has been used for an uncoupled protease-free assay of PPIase activity.

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VIP/PACAP Peptides

Synthesis of analogues of the thyreotropin releasing factor containing 2-oxoimidazolidine-1-carboxylic acid.

E.Kasafirek and M.Bartik, Coll. Czech. Chem. Commun., 45, 452 (1980)

Product inhibition of alpha-chymotrypsin in reverse micelles.

R.Bru and P.Walde, Eur. J. Biochem., 199, 95 (1991)

Potency variation of small-molecule chymase inhibitors across species.

J.Kervinen et al., Biochem. Pharmacol., 80, 1033 (2010)

Enzyme functionality and solvation of Subtilisin Carlsberg: from hours to femtoseconds.

J.K.A.Kamal et al., Chem. Phys. Lett., 387, 209 (2004)

Solution conformation of a cyclophilin-bound proline isomerase substrate.

L.T.Kakalis and I.M.Armitage, Biochemistry, 33, 1495 (1994)

Toward tailoring the specificity of the S1 pocket of subtilisin B. lentus: chemical modification of mutant enzymes as a strategy for removing specificity limitations.

G.DeSantis et al., Biochemistry, 38, 13391 (1999)

Potency variation of small-molecule chymase inhibitors across species.

J.Kervinen et al., Biochem. Pharmacol., 80, 1033 (2010)

Toward tailoring the specificity of the S1 pocket of subtilisin B. lentus: chemical modification of mutant enzymes as a strategy for removing specificity limitations.

G.DeSantis et al., Biochemistry, 38, 13391 (1999)

Determination of kinetic constants for peptidyl prolyl cis-trans isomerases by an improved spectrophotometric assay.

J.L.Kofron et al., Biochemistry, 30, 6127 (1991)

B.Janowski et al., Anal. Biochem., 252, 299 (1997)

A.J.Barrett, Meth. Enzymol., 80, 561 (1981)

Molecular weight: 624.65

Sum Formula: C₃₀H₃₆N₆O₉

Storage Temperature: < -15°C

Synonyms: SAAPNA

One Letter code: Suc-AAPF-pNA

Source: Synthetic

Old Product Number: L-1400

Substrates
Cathepsin G
Chymotrypsin
Pancreatic Elastase
Chymase
Brachyurin
Peptidylprolyl Isomerase

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