(D-Ala²,D-Leu⁵)-Enkephalin

H-Tyr-D-Ala-Gly-Phe-D-Leu-OH

Product Number: 4001508

CAS Number: 63631-40-3

€ 59.90 – € 428

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Product Description

DADLE has generally served as the putative, prototypical δ-opioid receptor ligand. DADLE is more potent and selective than Leu-enkephalin or Met-enkephalin in the MVD versus GPI bioassay systems and more potent and approximately as selective as Leu-enkephalin in binding assays. It shows roughly the same antinociceptive activity as β-endorphin.

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Cyclosporin H, Boc-MLF and Boc-FLFLF are antagonists that preferentially inhibit activity triggered through the formyl peptide receptor.

A.-L.Stenfeldt et al., Inflammation, 30, 224 (2007)

Comparison of the behavioral effects of beta-endorphin and enkephalin analogs.

E.T.Wei et al., Life Sci., 21, 321 (1977)

Discrete mapping of brain Mu and delta opioid receptors using selective peptides: quantitative autoradiography, species differences and comparison with kappa receptors.

N.A.Sharif and J.Hughes, Peptides, 10, 499 (1989)

Different types of opiate agonists interact distinguishably with mu, delta and kappa opiate binding sites.

A.Pfeiffer and A.Herz, Life Sci., 31, 1355 (1982)

Selectivity of various opioid peptides towards delta-, kappa; and mu-opioid receptors mediating presynaptic inhibition of neurotransmitter release in the brain.

A.H.Mulder et al., Neuropeptides, 14, 99 (1989)

Salt form: Acetate

Molecular weight: 569.66

Chemical Formula: C₂₉H₃₉N₅O₇

Storage Temperature: < -15°C

Synonyms: DADLE

One Letter code: YaGFl

Source: Synthetic

Old Product Number: H-2860

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