β-Endorphin (30-31) (bovine, camel, mouse, ovine)

H-Gly-Gln-OH

Product Number: 4001242

CAS Number: 13115-71-4

€ 178.70 – € 713.70

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Product Description

The dipeptide Gly-Gln, which is naturally derived from the posttranslational processing of β-endorphin, exhibited an inhibitory action on cell firing when applied iontophoretically to brainstem neurons in the rat. Moreover, it seems to be a neurotrophic regulator of acetylcholinesterase in the mammalian sympathetic ganglion. Gly-Gln suppressed morphine withdrawal symptoms in rats. As Ala-Gln, Gly-Gln has found use as a Gln source in parenteral nutrition.

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Utilization of tyrosine-containing dipeptides and N-acetyl-tyrosine in hepatic failure.

W.Druml et al., Hepatology, 21, 923 (1995)

Glycyl-glutamine, an endogenous beta-endorphin-derived peptide, inhibits morphine-induced conditioned place preference, tolerance, dependence, and withdrawal.

S.Cavun et al., J. Pharmacol. Exp. Ther., 315, 949 (2005)

Randomized, double-blind, controlled study of glycyl-glutamine-dipeptide in the parenteral nutrition of patients with acute leukemia undergoing intensive chemotherapy.

C.Scheid et al., Nutrition, 20, 249 (2004)

Postoperative glycyl-glutamine infusion reduces immunosuppression: partial prevention of the surgery induced decrease in HLA-DR expression on monocytes.

A.Spittler et al., Clin. Nutr., 20, 37 (2001)

Glycyl-L-glutamine antagonizes alpha-MSH-elicited thermogenesis.

G.E.Resch and W.R.Millington, Peptides, 14, 971 (1993)

Glycyl glutamine, an inhibitory neuropeptide derived from beta-endorphin.

D.C.Parish et al., Nature, 306, 267 (1983)

Isolation of glycylglutamine, the C-terminal dipeptide of the β-endorphin corticotropin prohormone.

D.C.Parish and D.G.Smyth, Biochem. Soc. Trans., 10, 221 (1982)

Direct neurotrophic action of glycyl-L-glutamine in the maintenance of acetylcholinesterase and butyrylcholinesterase in the preganglionically denervated superior cervical ganglion of the cat.

G.B.Koelle et al., Proc. Natl. Acad. Sci. USA, 84, 6944 (1987)

Effects of glycyl-L-glutamine and methylprednisolone on maintenance of acetylcholinesterase of transected rat sciatic nerves.

G.B.Koelle and M.S.Han, Proc. Natl. Acad. Sci. USA, 87, 9495 (1990)

Enhancement of acetylcholinesterase synthesis by glycyl-L-glutamine: an example of a small peptide that regulates differential transcription?

G.B.Koelle, Trends Pharmacol. Sci., 9, 318 (1988)

L.Haynes, Trends Pharmacol. Sci., 10, 136 (1989)

Molecular weight: 203.2

Chemical Formula: C₇H₁₃N₃O₄

Storage Temperature: < -15°C

Synonyms: β-Lipotropin (90-91)

One Letter code: GQ

Source: Synthetic

Old Product Number: N-1070

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