Tos-Phe-chloromethylketone

Tos-Phe-chloromethylketone

Product Number: 4000836

CAS Number: 402-71-1

€ 71.70 – € 285.70

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Product Description

TPCK irreversibly inhibits α-chymotrypsin, chymotrypsin-like serine proteases, and several cysteine proteases. Additionally, TPCK was shown to affect physiological events as proliferation and apoptosis in certain systems.

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Thimet oligopeptidase--a review of a thiol dependent metallo-endopeptidase also known as Pz-peptidase endopeptidase 24.15 and endo-oligopeptidase.

U.Tisljar, Biol. Chem. Hoppe-Seyler, 374, 91 (1993)

Apoptosis in human monocytic THP.1 cells involves several distinct targets of N-tosyl-L-phenylalanyl chloromethyl ketone (TPCK).

H.Zhu et al., Cell Death Differ., 4, 590 (1997)

Effect of a chymotrypsin-like inhibitor, TPCK, on histamine release from cultured human mast cells.

M.Yanagida et al., J. Pharm. Pharmacol., 49, 537 (1997)

Multiple effects of N-alpha-tosyl-L-phenylalanyl chloromethyl ketone (TPCK) on apoptotic pathways in human prostatic carcinoma cell lines.

O.W.Rokhlin et al., Cancer Biol. Ther., 3, 761 (2004)

Effect of the serine protease inhibitor N-tosyl-l-phenylalanine-chloromethyl ketone (TPCK) on MCF-7 mammary tumour cells growth and differentiation.

S.Horman et al., Cell Biol. Int., 24, 153 (2000)

Another biological effect of tosylphenylalanylchloromethane (TPCK): it prevents p47phox phosphorylation and translocation upon neutrophil stimulation.

M.Gillibert et al., Biochem. J., 386, 549 (2005)

Serine protease inhibitors N-alpha-tosyl-L-lysinyl-chloromethylketone (TLCK) and N-tosyl-L-phenylalaninyl-chloromethylketone (TPCK) are potent inhibitors of activated caspase proteases.

I.Frydrych and P.Mlejnek, J. Cell. Biochem., 103, 1646 (2008)

Molecular weight: 351.85

Sum Formula: C₁₇H₁₈ClNO₃S

Storage Temperature: < -15°C

Synonyms: TPCK

Source: Synthetic

Old Product Number: N-1160

Inhibitors
Cathepsin B
Cathepsin G
Cathepsin H
Cathepsin L
Chymase
Chymotrypsin
Papain
Tripeptide Aminopeptidase
Cerevisin
Protein Kinase
Tryptase
Lactosylceramide α-2,3-Sialyltransferase
Leucyl Endopeptidase
Vignain
Legumain
Gingipain R
Peptidyl-Lys Metalloendopeptidase
Envelysin

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