H-Leu-OMe · HCl

H-Leu-OMe · HCl

Product Number: 4000607

CAS Number: 7517-19-3

CHF 123.10

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Product Description

Leu-OMe (LME) causes lysosomal disruption and death of human monocytes (M phi). In addition, LME removed natural killer cell (NK) activity from human peripheral mononuclear cells (PBM). During incubation of human lymphocytes with Leu-OMe, the dipeptide Leu-Leu-OMe which is responsible for the NK-toxicity, is formed.

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Regulation of cellular function by products of lysosomal enzyme activity: elimination of human natural killer cells by a dipeptide methyl ester generated from L-leucine methyl ester by monocytes or polymorphonuclear leukocytes.

C.H.Görbitz, Chem. Eur. J., 7, 5133 (2001)

Modulation of human natural killer cell function by L-leucine methyl ester: monocyte-dependent depletion from human peripheral blood mononuclear cells.

D.L.Thiele and P.E.Lipsky, Proc. Natl. Acad. Sci. USA, 82, 2468 (1985)

D.L.Thiele and P.E.Lipsky, J. Immunol., 134, 786 (1985)

Molecular weight: 181.66

Chemical Formula: C₇H₁₅NO₂ · HCl

Storage Temperature: +5 ± 3 °C

Old Product Number: E-2080

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