Liver Cell Growth Factor

H-Gly-His-Lys-OH

Product Number: 4000308

CAS Number: 72957-37-0

€ 88.80 – € 267.50

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Product Description

GHK possesses a high affinity for copper(II) ions, with which it spontaneously forms a complex (GHK-Cu). This growth-modulating plasma tripeptide, when added at nanomolar concentrations to a wide group of cultured systems, produces a disparate set of responses ranging from the stimulation of growth and differentiation to outright toxicity. It may function by facilitating copper uptake into cells. GHK-Cu accelerates wound healing. CAS Number (net): 49557-75-7.

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Copper(II) complexes containing N,N-donor ligands and dipeptides act as hydrolytic DNA-cleavage agents.

P.R.Reddy et al., Chem. Biodivers., 1, 839 (2004)

Biological activity of human plasma copper-binding growth factor glycyl-L-histidyl-L-lysine.

L.Pickart and S.Lovejoy, Meth. Enzymol., 147, 314 (1987)

Stimulation of collagen synthesis in fibroblast cultures by the tripeptide-copper complex glycyl-L-histidyl-L-lysine-Cu2+.

F.-X.Maquart et al., FEBS Lett., 238, 343 (1988)

N.m.r. and e.p.r. investigation of the interaction of copper(II) and glycyl-L-histidyl-L-lysine, a growth-modulating tripeptide from plasma.

J.-P.Laussac et al., Biochem. J., 209, 533 (1983)

The interaction of copper(II) and glycyl-L-histidyl-L-lysine, a growth-modulating tripeptide from plasma.

S.-J.Lau and B.Sarkar, Biochem. J., 199, 649 (1981)

Salt form: Acetate

Molecular weight: 340.38

Chemical Formula: C₁₄H₂₄N₆O₄

Storage Temperature: < -15°C

Synonyms: GHK

One Letter code: GHK

Source: Synthetic

Old Product Number: H-3510

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