Return to Previous Page
Details
SEVNLDAEF corresponds to the mutant junctional sequence of the amyloid precursor protein (APP) found in a Swedish family with early-onset Alzheimer's disease, therefore referred to as the 'Swedish' mutation (K670N/M671L). The peptide has been used for assaying cleavage at leucine-aspartate by cathepsin G and chymotrypsin, whereas neither cathepsin B, D nor L generated any products.
Catalog Number
H-4836
APC Number
81-3-25
One Letter Code
SEVNLDAEF
Synonyms
(Asn⁶⁷⁰,Leu⁶⁷¹)-APP₇₇₀ (667-675), APP₇₇₀ (667-675) Swedish Mutation, (Asn670, Leu671)-Amyloid β/A4 Protein Precursor770 (667-675)
Molecular Formula
C₄₄H₆₆N₁₀O₁₈
Relative Molecular Mass
1023.07
CAS Registry Number
150234-52-9
Source
Synthetic
Storage Conditions
-20 ± 5 °C
Application
Alzheimer's Disease
Links / Documents:
Brochures:
4029477
| Enzyme | Substrates | Inhibitors |
|---|---|---|
| β-Secretase | ||
| Cathepsin G | ||
| Chymotrypsin |
