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4031157

Availability: In stock

PACAP-38 (human, mouse, ovine, porcine, rat) trifluoroacetate salt
H-His-Ser-Asp-Gly-Ile-Phe-Thr-Asp-Ser-Tyr-Ser-Arg-Tyr-Arg-Lys-Gln-Met-Ala-Val-Lys-Lys-Tyr-Leu-Ala-Ala-Val-Leu-Gly-Lys-Arg-Tyr-Lys-Gln-Arg-Val-Lys-Asn-Lys-NH₂ trifluoroacetate salt

4031157

Product No. Pack Size Available ADS InfoAnalytical Data Sheet List Price Online Order Price Qty
4031157.0200 0.2 mg Ships within 1 business day ADSExemplary Data Sheet of a current available lot.
CHF 166.00
CHF 154.38 (7%)
4031157.0500 0.5 mg Ships within 1 business day ADSExemplary Data Sheet of a current available lot.
CHF 368.00
CHF 342.24 (7%)
4031157.1000 1 mg Ships within 3-5 business days  
CHF 662.00
CHF 615.66 (7%)

Details

Kojro et al. observed that the PAC1 agonists PACAP-27 (H-1172) and PACAP-38 strongly increased the activity of α-secretase. Upregulation of this APP-degrading enzyme promotes the non-amyloidogenic processing of APP, i.e. reduces the production of Aβ40/42, and thus may help to prevent Alzheimer’s disease. Nasally applied PACAP-38 in APP[V717I]-transgenic mice additionally enhanced the production of the Aβ-degrading enzyme neprilysin via induction of somatostatin.
Catalog Number H-8430
APC Number 34-0-20
One Letter Code HSDGIFTDSYSRYRKQMAVKKYLAAVLGKRYKQRVKNK-NH₂
Synonyms PACAP (1-38), human, ovine, rat, Pituitary Adenylate Cyclase Activating Polypeptide-38 (human, mouse, ovine, porcine, rat)
Molecular Formula C₂₀₃H₃₃₁N₆₃O₅₃S
Relative Molecular Mass 4534.32
CAS Registry Number 124123-15-5
Source Synthetic
Storage Conditions -20 ± 5 °C
Application Alzheimer's Disease
Links / Documents:
Brochures:

Bachem product citations

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Product citations

D.Rat et al., FASEB J., 25, 3208 (2011)
E.Kojro et al., FASEB J., 20, 512 (2006)
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