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Kojro et al. observed that the PAC1 agonists PACAP-27 (H-1172) and PACAP-38 strongly increased the activity of α-secretase. Upregulation of this APP-degrading enzyme promotes the non-amyloidogenic processing of APP, i.e. reduces the production of Aβ40/42, and thus may help to prevent Alzheimer’s disease. Nasally applied PACAP-38 in APP[V717I]-transgenic mice additionally enhanced the production of the Aβ-degrading enzyme neprilysin via induction of somatostatin.
Catalog Number
H-8430
APC Number
34-0-20
One Letter Code
HSDGIFTDSYSRYRKQMAVKKYLAAVLGKRYKQRVKNK-NH₂
Synonyms
PACAP (1-38), human, ovine, rat, Pituitary Adenylate Cyclase Activating Polypeptide-38 (human, mouse, ovine, porcine, rat)
Molecular Formula
C₂₀₃H₃₃₁N₆₃O₅₃S
Relative Molecular Mass
4534.32
CAS Registry Number
124123-15-5
Source
Synthetic
Storage Conditions
-20 ± 5 °C
Application
Alzheimer's Disease
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