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Details
Orexin A (OXA, hypocretin-1) is a hypothalamic neuropeptide regulating the feeding behavior. Central administration of orexin A to rats stimulated food consumption in a dose-dependent manner. The effect persisted at 4 h after injection, as orexin A seems to be resistant to peptidases. Orexin A specifically binds a G protein-coupled receptor, OX₁R (IC₅₀ = 20 nM to displace 50 % of radiolabeled orexin A bound to this receptor). Orexin A produced in the amygdala induces wakefulness and plays a role in the induction of human emotions. Narcolepsy has been associated with orexin deficiency.
The peptide also corresponds to bovine, canine, ovine, and porcine orexin A.
Catalog Number
H-4172
APC Number
46-2-70
One Letter Code
pEPLPDCCRQKTCSCRLYELLHGAGNHAAGILTL-NH₂
Synonyms
Orexin A, human, bovine, rat, mouse, Hypocretin-1 (human, mouse, rat)
Molecular Formula
C₁₅₂H₂₄₃N₄₇O₄₄S₄
Relative Molecular Mass
3561.16
CAS Registry Number
205640-90-0
Source
Synthetic
Storage Conditions
-20 ± 5 °C
Application
Obesity Research
Parkinson's Disease
Parkinson's Disease
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