Shopping Cart - CHF 0.00

You have no items in your shopping cart.

Return to Previous Page
4028262

Availability: In stock

Orexin A (human, mouse, rat) trifluoroacetate salt
Pyr-Pro-Leu-Pro-Asp-Cys-Cys-Arg-Gln-Lys-Thr-Cys-Ser-Cys-Arg-Leu-Tyr-Glu-Leu-Leu-His-Gly-Ala-Gly-Asn-His-Ala-Ala-Gly-Ile-Leu-Thr-Leu-NH₂ trifluoroacetate salt (Disulfide bonds between Cys⁶ and Cys¹²/Cys⁷ and Cys¹⁴)

4028262

Product No. Pack Size Available ADS InfoAnalytical Data Sheet List Price Online Order Price Qty
4028262.0500 0.5 mg Ships within 1 business day ADSExemplary Data Sheet of a current available lot.
CHF 275.00
CHF 255.75 (7%)
4028262.1000 1 mg Ships within 1 business day ADSExemplary Data Sheet of a current available lot.
CHF 393.00
CHF 365.49 (7%)
4028262.5000 5 mg Ships within 1 business day ADSExemplary Data Sheet of a current available lot.
CHF 1,571.00
CHF 1,461.03 (7%)

Details

Orexin A (OXA, hypocretin-1) is a hypothalamic neuropeptide regulating the feeding behavior. Central administration of orexin A to rats stimulated food consumption in a dose-dependent manner. The effect persisted at 4 h after injection, as orexin A seems to be resistant to peptidases. Orexin A specifically binds a G protein-coupled receptor, OX₁R (IC₅₀ = 20 nM to displace 50 % of radiolabeled orexin A bound to this receptor). Orexin A produced in the amygdala induces wakefulness and plays a role in the induction of human emotions. Narcolepsy has been associated with orexin deficiency. H-4172 also corresponds to bovine, canine, ovine, and porcine orexin A.
Catalog Number H-4172
APC Number 46-2-70
One Letter Code pEPLPDCCRQKTCSCRLYELLHGAGNHAAGILTL-NH₂
Synonyms Hypocretin-1 (human, mouse, rat), Orexin A, human, bovine, rat, mouse
Molecular Formula C₁₅₂H₂₄₃N₄₇O₄₄S₄
Relative Molecular Mass 3561.16
CAS Registry Number 205640-90-0
Source Synthetic
Storage Conditions -20 ± 5 °C
Areas of Interest Obesity Research
Parkinson's Disease
Links / Documents:

Bachem product citations

L.Gac et al., Peptides, 76, 14 (2016)
C.Schone et al., Cell Rep., 7, 697 (2014)
M.Palotai et al., Peptides, 57, 129 (2014)
T.E.Fitch et al., Front. Neurosci., 8, 5 (2014)
M.Alvarez-Crespo et al., Endocrinology, 154, 3589 (2013)
G.M.Mang et al., Sleep, 35, 1625 (2012)
I.Z.Shahid et al., Br. J. Pharmacol., 165, 2292 (2012)
E.M.Stanley and J.R.Fadel, Neuroscience, 195, 70 (2011)
H.R.Sobhi et al., J. Chromatogr. A., 1218, 8536 (2011)
I.Z.Shahid et al., Br. J. Pharmacol., 162, 961 (2011)
T.Fenzl et al., Behav. Brain Res., 222, 43 (2011)
A.Deloumeau et al., PLoS One, 5, e13320 (2010)
M.Ozcan et al., Physiol. Res., 59, 255 (2010)
C.Anaclet et al., J. Neurosci., 29, 14423 (2009)
J.Wenzel et al., Am. J. Physiol. Regul. Integr. Comp. Physiol., 297, R1601 (2009)
A.Ziolkowska et al., Int. J. Mol. Med., 22, 749 (2008)
N.Ito et al., Neuroscience, 157, 720 (2008)
S.G.Nair et al., Br. J. Pharmacol., 154, 406 (2008)
A.K.Julliard et al., Behav. Brain Res., 183, 123 (2007)
J.Magga et al., Biochem. Pharmacol., 71, 827 (2006)
J.Nasman et al., J. Neurosci., 26, 10658 (2006)
N.M.Vittoz and C.W.Berridge, Neuropsychopharmacology, 31, 384 (2006)
A.B.Hardy et al., Endocrinology, 146, 4042 (2005)
A.Ziolkowska et al., J. Steroid Biochem. Mol. Biol., 96, 423 (2005)
M.Ehrstrom et al., J. Clin. Endocrinol. Metab., 90, 2370 (2005)
M.L.Barreiro et al., Endocrinology, 146, 5164 (2005)
R.Spinazzi et al., Int. J. Mol. Med., 15, 847 (2005)
L.M.Seoane et al., Eur. J. Endocrinol., 150, 731 (2004)
M.L.Barreiro et al., Endocrinology, 145, 2297 (2004)
G.Grabauskas and H.C.Moises, J. Physiol., 549, 37 (2003)
M.van den Top et al., J. Physiol., 549, 809 (2003)
R.Ouedraogo et al., Diabetes, 52, 111 (2003)
S.Hilairet et al., J. Biol. Chem., 278, 23731 (2003)
L.Bayer et al., J. Neurosci., 22, 7835 (2002)
V.Vogel et al., J. Neurosci. Methods, 118, 89 (2002)
Z.K.Krowicki et al., Am. J. Physiol. Gastrointest. Liver Physiol., 283, G465 (2002)
K.S.Eriksson et al., J. Neurosci., 21, 9273 (2001)
L.Bayer et al., Eur. J. Neurosci., 14, 1571 (2001)
M.Jaszberenyi et al., J. Neuroendocrinol., 12, 1174 (2000)

Product citations

A.M.Blouin et al., Nat. Commun., 4, 1547 (2013)
E.Göncz et al., Endocrinology, 149, 1618 (2008)
M.R.Jain et al., Regul. Pept., 87, 19 (2000)
M.W.Schwartz, Nat. Med., 4, 385 (1998)
T.Sakurai et al., Cell, 92, 573 (1998)
Related products