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Details
The fragment CHSGYVGVRC comprises the third disulfide loop of rat TGF α. Antibodies elicited against the synthetic decapeptide crossreacted with native TGF α but not EGF. The peptide competed with EGF for binding to its receptors and was found to be an antagonist of EGF-induced mitogenesis. More recent results indicate that administration of TGF α (34-43) inhibits the development of gastric cancers induced by N-methyl-N'-nitro-N-nitrosoguanidine.
Catalog Number
H-9195
APC Number
50-5-22
One Letter Code
CHSGYVGVRC
Molecular Formula
C₄₄H₆₇N₁₅O₁₃S₂
Relative Molecular Mass
1078.24
CAS Registry Number
97474-88-9
Source
Synthetic
Storage Conditions
-20 ± 5 °C
Application
Cancer Research
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