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Availability: In stock

Z-Val-Ala-DL-Asp-fluoromethylketone

4026865

Product No. Pack Size Available ADS InfoAnalytical Data Sheet Unit Price Online Order Price Qty
4026865.0005 5 mg Ships within 1 business day ADSExemplary Data Sheet of a current available lot.
CHF 315.00
CHF 292.95 (7%)
4026865.0025 25 mg Ships within 1 business day ADSExemplary Data Sheet of a current available lot.
CHF 1,261.00
CHF 1,172.73 (7%)
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Details

zVAD-FMK inhibited apoptosis induced by diverse stimuli. Preincubation of cells with this caspase-1 (ICE) inhibitor (50 µM) almost completely inhibited the formation of large kilobase-pair fragments of DNA, a characteristic biochemical change associated with apoptosis.
Z-VAD-FMK was shown to irreversibly inhibit most types of caspases, hence it is also called pan-caspase inhibitor. For a cell-permeable analog see N-1560,
Inhibitor of peptide:N-glycanase (PNGase).
Catalog Number N-1510
Synonyms Z-VAD-FMK
Molecular Formula C₂₁H₂₈FN₃O₇
Relative Molecular Mass 453.47
CAS Registry Number [220644-02-0]
Source Synthetic
Storage Conditions -20 ± 5 °C
Keywords Pan-caspase inhibitor

Bachem product citations

S.B.Berger et al., Cell Death Discov., 1, 15009 (2015)
X.S.Sun et al., J. Cancer Ther., 2, 418 (2011)
M.S.I.Abaza, Exp. Ther. Med, 1, 675 (2010)

4026865

Enzyme Substrates Inhibitors
Caspase-1 (ICE)    
Peptide-N4-(N-Acetyl-β-glucosaminyl)asparagine Amidase (PNGase)