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Availability: In stock

Angiotensin I-Converting Enzyme (ACE) Inactivator
Cyanoac-Phe-Phe-OH

4019609

Product No. Pack Size Available ADS InfoAnalytical Data Sheet Unit Price Online Order Price Qty
4019609.0250 250 mg Ships within 1 business day ADSExemplary Data Sheet of a current available lot.
CHF 473.00
CHF 439.89 (7%)
4019609.1000 1 g Ships within 3-5 business days  
CHF 1,419.00
CHF 1,319.67 (7%)
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Details

ACE-mediated deprotonation of cyanoacetyl-Phe-Phe leads to the formation of a ketenimine intermediate. This reactive intermediate, in turn, traps an active-site nucleophile to irreversibly inactivate the enzyme. This principle therefore seems to be suitable for the development of irreversible inactivators of therapeutically important zinc metalloproteases.
Catalog Number N-1360
APC Number 12-1-19
Molecular Formula C₂₁H₂₁N₃O₄
Relative Molecular Mass 379.42
CAS Registry Number [144085-32-5]
Source Synthetic
Storage Conditions -20 ± 5 °C

4019609

Enzyme Substrates Inhibitors
Peptidyl-Dipeptidase A    
Angiotensin I-Converting Enzyme (ACE)