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4026036

Availability: In stock

Mca-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH₂ trifluoroacetate salt

4026036

Product No. Pack Size Available ADS InfoAnalytical Data Sheet List Price Online Order Price Qty
4026036.0001 1 mg Ships within 1 business day ADSExemplary Data Sheet of a current available lot.
CHF 252.00
CHF 234.36 (7%)
4026036.0005 5 mg Ships within 1 business day ADSExemplary Data Sheet of a current available lot.
CHF 1,009.00
CHF 938.37 (7%)

Details

Mca-PLGL-Dpa-AR-amide is a very sensitive FRET substrate for continuous assays and in situ determination of the matrix metalloproteinase activity. Cleavage at the Gly-Leu bond separates the highly fluorescent Mca group from the efficient 2,4-dinitrophenyl quencher, resulting in an increase in fluorescence intensity. The kcat/Km values for the punctuated metalloproteinase (MMP-7) and for gelatinase (MMP-2), e.g., are 1.7·10⁵ and 6.3·10⁵ M⁻¹s⁻¹, respectively.
Catalog Number M-1895
APC Number 81-0-11
One Letter Code Mca- PLGL-Dpa-AR -NH₂
Synonyms 7-Methoxycoumarin-4-Acetyl-Pro-Leu-Gly-Leu-Dnp-(2,3-Diaminopropionyl)-Ala-Arg, amide
Molecular Formula C₄₉H₆₈N₁₄O₁₅
Relative Molecular Mass 1093.16
CAS Registry Number 140430-53-1
Source Synthetic
Storage Conditions -20 ± 5 °C
Application Cancer Research
Links / Documents:

Bachem product citations

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Product citations

L.Zhu et al., Arch. Oral Biol., 53, 785 (2008)
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4026036

Enzyme Substrates Inhibitors
Gelatinase A    
Matrilysin    
Stromelysin 1    
Matrix Metalloproteinase-2 (MMP-2)    
Matrix Metalloproteinase-7 (MMP-7)    
Matrix Metalloproteinase-3 (MMP-3)    
Gelatinase B    
Matrix Metalloproteinase-9 (MMP-9)    
Stromelysin-2    
Matrix Metalloproteinase-10 (MMP-10)    
Matrix Metalloproteinase-14 (MMP-14)    
Matrix Metalloproteinase-25 (MMP-25)    
Matrix Metalloproteinase-20 (MMP-20)    
Napsin    
Thermolysin    
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