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Details
A reversible inhibitor of Ser and Cys proteases with an activity spectrum comparable to leupeptin (N-1000). H-1765 inhibited transformation of NIH3T3 cells after transfection with an activated H-ras oncogene (Cox et al.). Vaccari et al. used antipain for evaluating the role of proteases in the process of malignant transformation of BALB/c 3T3 cells.
Catalog Number
H-1765
Molecular Formula
C₂₇H₄₄N₁₀O₆
Relative Molecular Mass
604.71
CAS Registry Number
37691-11-5
EINECS Number
253-631-0
Source
Synthetic
Storage Conditions
-20 ± 5 °C
Keywords
Inhibitor of Cys- and Ser-proteases
Application
Cancer Research
Links / Documents:
4030290
| Enzyme | Substrates | Inhibitors |
|---|---|---|
| Clostripain | ||
| Peptidyl-Lys Metalloendopeptidase | ||
| Tissue Kallikrein | ||
| Plasmin | ||
| Calpain | ||
| Carboxypeptidase C | ||
| Acrosin | ||
| Oligopeptidase B | ||
| Thermitase | ||
| Cathepsin B | ||
| Cathepsin D | ||
| Cathepsin L | ||
| Papain | ||
| Furin | ||
| Granzyme B | ||
| Tripeptide Aminopeptidase | ||
| Cerevisin | ||
| Subtilisin | ||
| Thrombin (Coagulation Factor IIa) | ||
| Trypsin | ||
| Tryptase | ||
| u-Plasminogen Activator | ||
| Gingipain R | ||
| Calpain-2 | ||
| Cathepsin T |
