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Details
A reversible inhibitor of Ser and Cys proteases with an activity spectrum comparable to leupeptin. Antipain inhibited transformation of NIH3T3 cells after transfection with an activated H-ras oncogene (Cox et al.). Vaccari et al. used antipain for evaluating the role of proteases in the process of malignant transformation of BALB/c 3T3 cells.
Catalog Number
H-1765
Molecular Formula
C₂₇H₄₄N₁₀O₆
Relative Molecular Mass
604.71
CAS Registry Number
37691-11-5
EINECS Number
253-631-0
Source
Synthetic
Storage Conditions
-20 ± 5 °C
Keywords
Inhibitor of Cys- and Ser-proteases
Application
Cancer Research
Links / Documents:
4030290
Enzyme | Substrates | Inhibitors |
---|---|---|
Clostripain | ||
Peptidyl-Lys Metalloendopeptidase | ||
Tissue Kallikrein | ||
Plasmin | ||
Calpain | ||
Carboxypeptidase C | ||
Acrosin | ||
Oligopeptidase B | ||
Thermitase | ||
Cathepsin B | ||
Cathepsin D | ||
Cathepsin L | ||
Papain | ||
Furin | ||
Granzyme B | ||
Tripeptide Aminopeptidase | ||
Cerevisin | ||
Subtilisin | ||
Thrombin (Coagulation Factor IIa) | ||
Trypsin | ||
Tryptase | ||
u-Plasminogen Activator | ||
Gingipain R | ||
Calpain-2 | ||
Cathepsin T |