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Details
L-DON, which corresponds to Glu γ-diazomethyl ketone, inactivates rat renal phosphate-dependent glutaminase and is active against various tumor systems. Irreversible inhibitor of γ-glutamyl transferase (γ-GT).
Catalog Number
F-1510
Synonyms
6-Diazo-5-oxo-L-2-aminohexanoic acid, L-DON, H-Glu(diazomethylketone)-OH
Molecular Formula
C₆H₉N₃O₃
Relative Molecular Mass
171.16
CAS Registry Number
157-03-9
Storage Conditions
-20 ± 5 °C
Keywords
Glutaminase inhibitor
Application
Cancer Research
Links / Documents:
Bachem product citations
Product citations
G.R.Pettit and P.S.Nelson,
J. Org. Chem.,
48,
741 (1983)
4006579
Enzyme | Substrates | Inhibitors |
---|---|---|
γ-Glutamyltransferase | ||
Glutamate Synthase (NADH) | ||
Amidophosphoribosyltransferase | ||
Glutamine-Fructose-6-Phosphate Transaminase (Isomerizing) | ||
Phosphoribosylformylglycinamidine Synthase | ||
Glutaminase |