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4006579

Availability: In stock

H-6-Diazo-5-oxo-Nle-OH

4006579

Product No. Pack Size Available ADS InfoAnalytical Data Sheet List Price Online Order Price Qty
4006579.0100 100 mg Ships within 1 business day ADSExemplary Data Sheet of a current available lot.
CHF 252.00
CHF 234.36 (7%)
4006579.0500 500 mg Ships within 1 business day ADSExemplary Data Sheet of a current available lot.
CHF 1,009.00
CHF 938.37 (7%)

Details

L-DON, which corresponds to Glu γ-diazomethyl ketone, inactivates rat renal phosphate-dependent glutaminase and is active against various tumor systems. Irreversible inhibitor of γ-glutamyl transferase (γ-GT).
Catalog Number F-1510
Synonyms 6-Diazo-5-oxo-L-2-aminohexanoic acid, L-DON, H-Glu(diazomethylketone)-OH
Molecular Formula C₆H₉N₃O₃
Relative Molecular Mass 171.16
CAS Registry Number 157-03-9
Storage Conditions -20 ± 5 °C
Keywords Glutaminase inhibitor
Application Cancer Research
Links / Documents:

Bachem product citations

A.A.Hoskins et al., Biochemistry, 43, 10314 (2004)
F.Reimann et al., Diabetologia, 47, 1592 (2004)
F.Hausch et al., Chem. Biol., 10, 225 (2003)

Product citations

G.R.Pettit and P.S.Nelson, J. Org. Chem., 48, 741 (1983)
R.A.Shapiro et al., J. Biol. Chem., 254, 2835 (1979)

4006579

Enzyme Substrates Inhibitors
γ-Glutamyltransferase    
Glutamate Synthase (NADH)    
Amidophosphoribosyltransferase    
Glutamine-Fructose-6-Phosphate Transaminase (Isomerizing)    
Phosphoribosylformylglycinamidine Synthase    
Glutaminase