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Details
The fluorogenic substrate Suc-LLVY-AMC is used for measuring the chymotrypsin-like activity of the 20S proteasome, in combination with e.g. Bz-VGR-AMC (for assaying its trypsin-like activity) and Z-LLE-AMC (for determining its PGPH activity).
Suc-LLVY-AMC is also cleaved by a chymotrypsin-like enzyme from sperm extract of the ascidian Halocynthia roretzi, a strong inhibitor of fertilization. The substrate has also been used to analyze the chymotrypsin-like activity of trypsins as well as chymase from rat mast cells. Furthermore, Suc-LLVY-AMC is a substrate for carboxypeptidase Y, proteinase yscE (kexin), ingensin, as well as for porcine calpain isozymes I and II and for papain.
Catalog Number
I-1395
APC Number
81-1-07
One Letter Code
Suc-LLVY-AMC
Synonyms
Chymotrypsin Substrate III, Fluorogenic
Molecular Formula
C₄₀H₅₃N₅O₁₀
Relative Molecular Mass
763.89
CAS Registry Number
94367-21-2
Source
Synthetic
Storage Conditions
-20 ± 5 °C
Links / Documents:
Bachem product citations
T.-L.Chang et al.,
Journal of Functional Foods,
17,
857 (2015)
F.Gonzalez,
Nat. Prod. Chem. Res.,
2,
(2014)
N.Basse et al.,
Comptes Rendus Chimie,
12,
1163 (2009)
Product citations
4011369
Enzyme | Substrates | Inhibitors |
---|---|---|
Chymase | ||
Papain | ||
Multicatalytic Endopeptidase Complex | ||
Calpain | ||
Carboxypeptidase C | ||
Calpain-2 | ||
Envelysin | ||
Proteasome Endopeptidase Complex | ||
Kexin |