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(Nle³⁵)-Amyloid β-Protein (1-40) ammonium salt
H-Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Nle-Val-Gly-Gly-Val-Val-OH ammonium salt

4041778

Product No. Pack Size Available ADS InfoAnalytical Data Sheet Unit Price Online Order Price Qty
4041778.0500 0.5 mg Ships within 1 business day ADSExemplary Data Sheet of a current available lot.
CHF 152.00
CHF 141.36 (7%)
4041778.1000 1 mg Ships within 1 business day ADSExemplary Data Sheet of a current available lot.
CHF 254.00
CHF 236.22 (7%)
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Details

The reactive thioether of Met³⁵ is crucial for the activity of Aβ 1-40 and Aβ 1-42. Due to the replacement of Met by inert Nle, M35Nle Aβ 1-40 was no longer toxic to cultured hippocampal neurons and had little effect on the level of protein carbonyl residues. The Nle peptide showed the same propensity to aggregate, whereas sulfoxide formation hindered the required conformational transition from random coil to β-sheet.
Catalog Number H-7312
Synonyms (Nle³⁵) β-Amyloid (1-40)
Molecular Formula C₁₉₅H₂₉₇N₅₃O₅₈
Relative Molecular Mass 4311.83
CAS Registry Number [1802086-31-2]
Source Synthetic
Storage Conditions -20 ± 5 °C
Areas of Interest Alzheimer's Disease