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Availability: In stock

IGF-I (1-3)
H-Gly-Pro-Glu-OH

4026104

Product No. Pack Size Available ADS InfoAnalytical Data Sheet Unit Price Online Order Price Qty
4026104.0250 250 mg Ships within 1 business day ADSExemplary Data Sheet of a current available lot.
CHF 126.00
CHF 117.18 (7%)
4026104.1000 1 g Ships within 1 business day ADSExemplary Data Sheet of a current available lot.
CHF 378.00
CHF 351.54 (7%)
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Details

This N-terminal tripeptide of IGF-I facilitated the in vitro release of acetylcholine with a several hundredfold higher potency (10⁻¹⁰ - 10⁻⁶ M) than intact IGF-I (4 · 10⁻⁸ M), whereas truncated IGF-I lacking the tripeptide GPE, did not show any significant effect. This raises the possibility that GPE may be the active site of IGF-I. - Although the precise mode of action of GPE is still unknown, another study suggests that local administration of GPE is neuroprotective after brain HI injury via glial cells. In addition, systemic administration of GPE showed a more widespread neuroprotective effect. Therefore, GPE may represent a complementary pathway for central and systemic IGF-1's antiapoptotic effects.
Catalog Number H-2468
One Letter Code GPE
Synonyms GPE
Molecular Formula C₁₂H₁₉N₃O₆
Relative Molecular Mass 301.30
CAS Registry Number [32302-76-4]
Source Synthetic
Storage Conditions -20 ± 5 °C
Areas of Interest Di- and Tripeptides
Diabetes