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Availability: In stock

Z-Ile-Glu(OtBu)-Ala-Leu-aldehyde

4026408

Product No. Pack Size Available ADS InfoAnalytical Data Sheet Unit Price Online Order Price Qty
4026408.0005 5 mg Ships within 1 business day ADSExemplary Data Sheet of a current available lot.
CHF 158.00
CHF 146.94 (7%)
4026408.0025 25 mg Ships within 1 business day ADSExemplary Data Sheet of a current available lot.
CHF 630.00
CHF 585.90 (7%)
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Details

Z-IE(OtBu)AL-CHO is an inhibitor of chymotrypsin-like activity of the multicatalytic proteinase complex (MPC; 20S proteasome) in HT4 cells. It is the first inhibitor reported so far which can cause accumulation of ubiquitinylated proteins in neuronal cells. Furthermore, this compound induced massive apoptosis in murine leukaemia L1210 cells. Therefore, proteasome inhibitors may be considered as potential anti-neoplastic agents.
Catalog Number C-3900
Synonyms PSI, Proteasome Inhibitor I, Z-Ile-Glu(OtBu)-Ala-L-leucinal
Molecular Formula C₃₂H₅₀N₄O₈
Relative Molecular Mass 618.77
CAS Registry Number [158442-41-2]
Source Synthetic
Storage Conditions -20 ± 5 °C

4026408

Enzyme Substrates Inhibitors
Multicatalytic Endopeptidase Complex    
Proteasome Endopeptidase Complex