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Availability: In stock

Fmoc-Asp(OtBu)-(Hmb)Gly-OH

4035481

Product No. Pack Size Available ADS InfoAnalytical Data Sheet Unit Price Online Order Price Qty
4035481.0001 1 g Ships within 1 business day ADSExemplary Data Sheet of a current available lot.
CHF 305.00
CHF 283.65 (7%)
4035481.0005 5 g Ships within 1 business day ADSExemplary Data Sheet of a current available lot.
CHF 1,156.00
CHF 1,075.08 (7%)
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Details

Aspartimide formation of the highly base-labile Asp-Gly motif during Fmoc-SPPS may be completely suppressed by coupling this Hmb-protected dipeptide derivative. Additionally, Hmb prevents aggregation of the growing peptide chain as efficiently as the incorporation of a pseudoproline moiety. O-Acylation renders the Hmb moiety acid-stable facilitating the purification of peptides prone to form aggregates. The acyl group can be removed with hydrazine hydrate in DMF (cf. Quibell).
Catalog Number B-3650
Synonyms Fmoc-Asp(OtBu)-N-(2-hydroxy-4-methoxy-Bzl)-Gly-OH
Molecular Formula C₃₃H₃₆N₂O₉
Relative Molecular Mass 604.67
CAS Registry Number [502640-94-0]
Storage Conditions -20 ± 5 °C
Keywords Dipeptide building block

Product citations

M.Quibell et al., J. Chem. Soc., Perkin Trans. I, 2019 (1995)