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Details
An LRF-amide motif containing fragment of malignant melanoma metastasis suppressor KiSS-1. It bound with low nanomolar affinity to the rat and human G protein-coupled receptor GPR54 expressed in Chinese hamster ovary K1 cells and stimulated PIP₂ hydrolysis, Ca²⁺ mobilization, arachidonic acid release, ERK1/2 and p38 MAP kinase phosphorylation, and stress fiber formation but inhibited cell proliferation.
Catalog Number
H-5962
APC Number
55-0-17
One Letter Code
LPNYNWNSFGLRF-NH₂
Synonyms
Malignant Melanoma Metastasis-Suppressor KiSS-1 (109-121) (human), Kisspeptin-14 (2-14) (human), KiSS-1 (109-121) (human), Metastin (42-54) (human), Kisspeptin-54 (42-54) (human)
Molecular Formula
C₇₈H₁₀₇N₂₁O₁₈
Relative Molecular Mass
1626.84
CAS Registry Number
374675-18-0
Source
Synthetic
Storage Conditions
-20 ± 5 °C
Application
Cancer Research
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