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Details
Aggregation of α-synuclein (α-syn) into toxic fibrils is a pathogenic hallmark of Parkinson’s disease (PD). Most early onset mutations are located between residues 46-53. The sequence of α-synuclein (45-54) was used by Cheruvara and coworkers as a template for a peptide library. The authors isolated a 10-residue peptide antagonist that potently inhibits α-synuclein aggregation and associated toxicity at 1:1 stoichiometry.
Catalog Number
H-8376
One Letter Code
KEGVVHGVAT
Molecular Formula
C₄₃H₇₃N₁₃O₁₄
Relative Molecular Mass
996.12
CAS Registry Number
2243206-98-4
Source
Synthetic
Storage Conditions
-20 ± 5 °C
Application
Alzheimer's Disease
Parkinson's Disease
Parkinson's Disease
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