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Experiments using sub-peptides of Aβ42 revealed that the epitope identified by the antibody A8, as described by Ying and coworkers, lies within the 1-6 region of Aβ. The antibody displays high affinity for soluble Aβ42 oligomers in the molecular weight range of 16.5-25 kDa, and detected target antigen in brain sections from senescence-accelerated SAMP 8 mice. Amidated or acetylated and amidated forms of the sequence were used for example for quantitative structure retention relationships (QSRR) experiments. The latter could allow prediction of reversed-phase high-performance liquid chromatography (HPLC) retention of peptides, as reported by Kaliszan and coworkers.
Catalog Number
H-8366
One Letter Code
DAEFRH-NH₂
Molecular Formula
C₃₃H₄₈N₁₂O₁₀
Relative Molecular Mass
772.81
CAS Registry Number
903883-21-6
Source
Synthetic
Storage Conditions
-20 ± 5 °C
Application
Alzheimer's Disease
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