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Details
Depletion of NEK11 prevents proteasome-dependent degradation of CDC25A, both in unperturbed and DNA-damaged cells. In addition, NEK11 directly phosphorylates CDC25A, and CHK1 (checkpoint kinase 1) directly activates NEK11 by phosphorylating it on Ser²⁷³. Taken together, NEK11 is an important component of the pathway enforcing the G2/M checkpoint, and genetic mutations in NEK11 may contribute to the development of cancer. These results have been shown by Melixetian and coworkers.
Catalog Number
H-8312
One Letter Code
LNKNP(p)SLRPSAIEILC
Molecular Formula
C₇₇H₁₃₅N₂₂O₂₆PS
Relative Molecular Mass
1848.09
CAS Registry Number
2243207-06-7
Source
Synthetic
Storage Conditions
-20 ± 5 °C
Application
Cancer Research
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