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Details
Human defensin-5 (HD 5) is a key regulator of gut microbiota homeostasis. HD 5 exhibits microbicidal activity against bacteria, fungi, and viruses and is released by Paneth cells in the small intestine.
Reduction or absence of HD 5 release in the intestinal mucosa has been associated with susceptibility to enteric pathogens, changes in composition of the microbiota, and disruption of intestinal immune homeostasis.
As a biomarker, HD 5 might be used to distinguish between ulcerative colitis (low levels of HD 5) or Crohn's colitis (high levels of HD 5).
Reduction or absence of HD 5 release in the intestinal mucosa has been associated with susceptibility to enteric pathogens, changes in composition of the microbiota, and disruption of intestinal immune homeostasis.
As a biomarker, HD 5 might be used to distinguish between ulcerative colitis (low levels of HD 5) or Crohn's colitis (high levels of HD 5).
Catalog Number
H-8252
One Letter Code
ATCYCRTGRCATRESLSGVCEISGRLYRLCCR
Synonyms
Defensin HD 5, HD 5, Human α-defensin 5, α-Defensin 5 (human)
Molecular Formula
C₁₄₄H₂₃₈N₅₀O₄₅S₆
Relative Molecular Mass
3582.18
Source
Synthetic
Storage Conditions
-20 ± 5 °C
Areas of Interest
Antimicrobial & Antiviral Peptides
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