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Details
The lipopeptide FSL-1, synthesized on the basis of the N-terminal structure of a M. salivarium lipoprotein, is capable of inducing the cell surface expression of ICAM-1 in human gingival fibroblasts. It furthermore revealed an activity to induce production of monocyte chemoattractant protein 1, interleukin-6 (IL-6), and IL-8. FSL-1 also activated macrophages to produce tumor necrosis factor alpha. Overall, results by Okusawa and coworkers suggest that the diacylglyceryl and the peptide portions of FSL-1 are indispensable for the expression of biological activities and for the recognition by Toll-like receptors 2 and 6. Furthermore, the same authors conclude that the recognition of FSL-1 by Toll-like receptors 2 and 6 apparently is hydrophobic.
Catalog Number
H-7926
One Letter Code
Pam₂CGDPKHPKSFDYKDDDDK
Synonyms
Fibroblast Stimulating Lipopeptide 1 FLAG-tag
Molecular Formula
C₁₂₅H₁₉₈N₂₄O₃₇S
Relative Molecular Mass
2661.15
CAS Registry Number
2243206-97-3
Source
Synthetic
Storage Conditions
-20 ± 5 °C
Application
Immunomodulating Agents
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