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Details
Orexin A (17-33) acts as selective OX1 antagonist. Truncation studies have led to OXA (17-33) as the shortest active peptide known to date with a 23-fold selectivity for OX1 over OX2. The native orexins A and B do not show distinct receptor selectivity. Both OX receptors are involved in energy homeostasis and the sleep/wake cycle, hence selective as well as dual antagonists are required for research.
Catalog Number
H-7526
One Letter Code
YELLHGAGNHAAGILTL
Synonyms
Hypocretin-1 (17-33)
Molecular Formula
C₇₉H₁₂₅N₂₃O₂₂
Relative Molecular Mass
1749.00
CAS Registry Number
343268-91-7
Source
Synthetic
Storage Conditions
-20 ± 5 °C
Application
Obesity Research
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