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Amyloid β-Protein (4-42) ammonium salt

4090138

Product No. Pack Size Available ADS InfoAnalytical Data Sheet List Price Online Order Price Qty
4090138.0500 0.5 Ships within 1 business day ADSExemplary Data Sheet of a current available lot.
CHF 505.00
CHF 469.65 (7%)

Details

Aβ 4-42 could be one of the earliest and most prominent Aβ species deposited in AD brain. Sequencing of amyloid plaque cores showed that 64% of the isolated Aβ had a phenylalanine at its N-terminus, and indeed, IP/MS experiments identified Aβ 4-42 as a major Aβ species in AD patients. Additionally, Aβ 4-42 was found to be a component of cotton wool plaques in familial AD patients with the V261I PS1 mutation. Aβ 4-42 was discovered as well in amyloid deposits from vascular dementia and familial Danish dementia patients. These observations indicate that Aβ 4-42 may contribute to the development of multiple CNS diseases.