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Details
Cerebral amyloid angiopathy (CAA) is a common finding in Alzheimer’s disease in which amyloid-Aβ vascular deposits are featured in >80% of the cases. Mutations in the positions 21-23 (e.g. Dutch mutation E22Q) are primarily associated with CAA, although they manifest with strikingly different clinical phenotypes: cerebral hemorrhage or dementia. The Piedmont L34V Aβ mutant, located outside this hot spot, shows a similar hemorrhagic phenotype, albeit less aggressive than the widely studied Dutch variant.
Catalog Number
H-7414
One Letter Code
DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGVMVGGVV
Synonyms
Amyloid β-Protein (1-40) Piedmont Mutation, Amyloid β-Protein (1-40) L34V
Molecular Formula
C₁₉₃H₂₉₃N₅₃O₅₈S
Relative Molecular Mass
4315.84
CAS Registry Number
1678415-83-2
Source
Synthetic
Storage Conditions
-20 ± 5 °C
Application
Alzheimer's Disease
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