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For a detailed description of Aβ 1-42, please see product H-1368.
For the preparation of Aβ for experimental use, Fezoui et al. (2000) found that solvation of synthetic peptide with sodium hydroxide (Aβ·NaOH) followed by lyophilization, produced stocks with superior solubility and fibrillogenesis characteristics. Solubilization of the pretreated material with neutral buffers resulted in a pH transition from ≈10.5 to neutral, avoiding the isoelectric point of Aβ (pI≈5.5), at which Aβ precipitation and aggregation propensity are maximal.
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