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Availability: In stock

Angiotensin A (1-7) trifluoroacetate salt

4084113

Product No. Pack Size Available ADS InfoAnalytical Data Sheet List Price Online Order Price Qty
4084113.0010 10 Ships within 1 business day ADSExemplary Data Sheet of a current available lot.
CHF 128.00
CHF 119.04 (7%)
4084113.0025 25 Ships within 1 business day ADSExemplary Data Sheet of a current available lot.
CHF 255.00
CHF 237.15 (7%)

Details

Alamandine can be formed from angiotensin A by action of ACE-2 or directly from angiotensin-(1-7) by decarboxylation of its aspartate residue. The angiotensin A analog produces effects resembling those of Ang II (1-7). However, it acts independently of the two known vasodilators receptors of the RAS (Mas and angiotensin II type 2). To produce its effects, alamandine binds to the Mas-related receptor, MrgD. A novel orally active formulation of alamandine produced a long-term antihypertensive effect in spontaneously hypertensive rats and cardioprotective effects. These novel findings will be helpful for developing a new understanding of the RAS, a key regulator of blood pressure and fluid balance. The heptapeptide could serve as a model peptide, e.g. in the development and evaluation of analytical methods.