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Details
The N-terminal Aβ fragments Aβ1-14, Aβ1-15 (H-6368), and Aβ1-16 (H-2958) are elevated in cell media and in CSF in response to γ-secretase inhibitor treatment. The presence of these small peptides is consistent with a catabolic amyloid precursor protein cleavage pathway by β- followed by α-secretase. It has been shown that Aβ1-14, Aβ1-15, and Aβ1-16 increase dose-dependently in response to γ-secretase inhibitor treatment while Aβ1-42 levels are unchanged.
Catalog Number
H-7372
One Letter Code
DAEFRHDSGYEVHH
Molecular Formula
C₇₃H₉₉N₂₃O₂₅
Relative Molecular Mass
1698.73
CAS Registry Number
[186319-74-4] net
Source
Synthetic
Storage Conditions
-20 ± 5 °C
Keywords
Biomarker
Areas of Interest
Alzheimer's Disease
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