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Details
SPLUNC1 is an endogenous inhibitor of the epithelial sodium channel (ENaC) which is responsible for Na⁺ and fluid absorption across colon, kidney, and airway epithelia. The partial sequence GGLPVPLDQTLPLNVNPA (SPLUNC1 22-39) corresponds to the ENaC inhibitory domain of SPLUNC1. As ENaC hyperactivity contributes to the development of cystic fibrosis in the lungs, the fragment could help to develop new strategies for the treatment of this genetic disorder.
Catalog Number
H-7352
One Letter Code
GGLPVPLDQTLPLNVNPA
Molecular Formula
C₈₂H₁₃₅N₂₁O₂₅
Relative Molecular Mass
1815.10
CAS Registry Number
[1421132-47-9] net
Source
Synthetic
Storage Conditions
-20 ± 5 °C
Areas of Interest
Ion Channel Modulating Agents
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