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Details
CALP-3, VKFGVGFK, acts as a calmodulin agonist. The octapeptide interacts with the calmodulin EF-hand motif, the Ca²⁺-binding site. CALP-3 activates phosphodiesterase in the absence of calcium and inhibits Ca²⁺-mediated cytotoxicity and apoptosis. CALP-3 is more active than CALP-1. By preventing trypsin activation within pancreatiic acinar cells CALP-3 shows potential therapeutic potential in the treatment of pancreatitis.
Catalog Number
H-7344
One Letter Code
VKFGVGFK
Synonyms
CALP-3
Molecular Formula
C₄₄H₆₈N₁₀O₉
Relative Molecular Mass
881.09
CAS Registry Number
261969-05-5
Source
Synthetic
Storage Conditions
-20 ± 5 °C
Keywords
Calmodulin agonist
Application
Apoptosis & Necrosis
Gastrointestinal Research
Gastrointestinal Research
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