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Details
The English (H6R) mutation of β-amyloid peptides accelerates fibrillation without increasing protofibril formation. Ono et al. showed that the English and Tottori mutations alter Abeta assembly at its earliest stages, monomer folding and oligomerization, and produce oligomers that are more toxic to cultured neuronal cells than are wild type oligomers.
The exchange of His⁶ by Arg influences the structure of the Cu(II) complex formed by Aβ peptides.
Catalog Number
H-7336
One Letter Code
DAEFRRDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVV
Synonyms
Amyloid β-Protein (1-40) H6R, Amyloid β-Protein (1-40) English Mutation
Molecular Formula
C₁₉₄H₃₀₀N₅₄O₅₈S
Relative Molecular Mass
4348.91
CAS Registry Number
1802084-26-9
Source
Synthetic
Storage Conditions
-20 ± 5 °C
Application
Alzheimer's Disease
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