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Details
The Tottori (D7N) mutation of β-amyloid peptides accelerates fibrillation without increasing protofibril formation. Ono et al. showed that the English and Tottori mutations alter Abeta assembly at its earliest stages, monomer folding and oligomerization, and produce oligomers that are more toxic to cultured neuronal cells than are wild type oligomers.
Catalog Number
H-7334
One Letter Code
DAEFRHNSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVV
Synonyms
Amyloid β-Protein (1-40) D7N, Amyloid β-Protein (1-40) Tottori Mutation
Molecular Formula
C₁₉₄H₂₉₆N₅₄O₅₇S
Relative Molecular Mass
4328.88
CAS Registry Number
383200-64-4
Source
Synthetic
Storage Conditions
-20 ± 5 °C
Application
Alzheimer's Disease
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