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Details
The central E region of fibrin contains two sets of polymerization knobs, A and B, that are cryptic in fibrinogen but become exposed after thrombin cleavage of fibrinopeptide A (FpA) and fibrinopeptide B (FpB) from the N-terminus of the Aα- and Bβ-chains, respectively. The location of the binding holes and possible models for knob-hole interactions are known from X-ray crystallographic studies using synthetic peptide analogs of knobs A and B. When fibrinogen fragment D and double-D are crystallized in the presence of both peptide analogs, the knob A peptide mimic H-Gly-Pro-Arg-Pro-NH₂ (GPRP-amide) forms H-bond interactions with residues γ364Asp, γ330Asp, γ329Gln, and γ340His found in hole a. In the same manner, the knob B peptide mimic H-Gly-His-Arg-Pro-NH₂ (GHRP-amide) interacts with residues Bβ397Glu, Bβ398Asp, and Bβ432Asp in hole b.
Catalog Number
H-7318
One Letter Code
GHRP-NH₂
Synonyms
GHRP amide
Molecular Formula
C₁₉H₃₂N₁₀O₄
Relative Molecular Mass
464.53
CAS Registry Number
209623-54-1
Source
Synthetic
Storage Conditions
-20 ± 5 °C
Application
Cardiovascular System & Diseases
Hematology
Hematology
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