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Details
A highly sensitive biomarker for the production of Aβ 1-42 derived from the βAPP-like protein APLP1. The peptide is generated by the same proteolytic mechanism as Aβ42. Non-amyloidogenic APL1β28 can be detected in the CSF and its levels correlate with Aβ42 production. Its ratio to total APL1β (APL1β25, APL1β27, and APL1β28) is significantly increased in familial and sporadic cases of AD.
Catalog Number
H-7306
One Letter Code
DELAPAGTGVSREAVSGLLIMGAGGGSL
Synonyms
APLP1-derived Aβ-like peptide (1-28)
Molecular Formula
C₁₀₉H₁₈₅N₃₁O₃₉S
Relative Molecular Mass
2585.92
CAS Registry Number
[1233876-42-0] net
Source
Synthetic
Storage Conditions
-20 ± 5 °C
Keywords
Biomarker
Areas of Interest
Alzheimer's Disease
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