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Details
GaTx1 is a component of the venom of the yellow scorpion (Leiurus quinquestriatus hebraeus). The highly bridged 34-peptide, a chloride channel ligand, potently and reversibly inhibits cystic fibrosis transmembrane conductance regulator (CFTR) chloride channels when the channels are in the interburst closed state. Since the toxin inhibits CFTR only when applied to the cytoplasmic side, it is unlikely that CFTR represents the native target.
Manufactured and sold under license from Georgia Tech Research Corporation, USA; patent WO/2007/137163 (PCT/US2007/069243).
Manufactured and sold under license from Georgia Tech Research Corporation, USA; patent WO/2007/137163 (PCT/US2007/069243).
Catalog Number
H-6678
One Letter Code
CGPCFTTDHQMEQKCAECCGGIGKCYGPQCLCNR-NH₂
Molecular Formula
C₁₄₇H₂₂₄N₄₆O₄₇S₉
Relative Molecular Mass
3676.27
CAS Registry Number
[1926163-15-6] net
Source
Synthetic
Storage Conditions
-20 ± 5 °C
Areas of Interest
Ion Channel Modulating Agents
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