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Details
Smac-N7 Peptide corresponds to the N-terminal seven residues of Smac (second mitochondria-derived activator of caspase) also known as DIABLO. Smac/DIABLO is a mitochondrial proapoptotic protein that activates caspases in the cytochrome c/Apaf-1/caspase-9 pathway by neutralizing inhibitor of apoptosis protein (IAP).
Smac-N7 peptide promoted procaspase-3 activation in vitro at around 10 µM and inhibited binding of caspase-9-p12 to the BIR3 (baculoviral IAP repeat 3) domain of XIAP (X-linked IAP).
The finding that Smac/DIABLO agonists could enhance the apoptosis-inducing potential of irradiation and chemotherapeutic drugs might lead to promising new candidates for cancer treatment.
Smac-N7 peptide promoted procaspase-3 activation in vitro at around 10 µM and inhibited binding of caspase-9-p12 to the BIR3 (baculoviral IAP repeat 3) domain of XIAP (X-linked IAP).
The finding that Smac/DIABLO agonists could enhance the apoptosis-inducing potential of irradiation and chemotherapeutic drugs might lead to promising new candidates for cancer treatment.
Catalog Number
H-6656
One Letter Code
AVPIAQK
Synonyms
Mitochondrial Diablo Homolog (1-7) (human, mouse), Second Mitochondria-derived Activator of Caspase (1-7) (human, mouse), Smac Protein (1-7) (human, mouse)
Molecular Formula
C₃₃H₅₉N₉O₉
Relative Molecular Mass
725.89
CAS Registry Number
[401913-57-3] net
Source
Synthetic
Storage Conditions
-20 ± 5 °C
Areas of Interest
Apoptosis & Necrosis
Cancer Research
Cancer Research
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