Shopping Cart - CHF 0.00

You have no items in your shopping cart.

Return to Previous Page

Availability: Out of stock

Smac-N7 Peptide trifluoroacetate salt
H-Ala-Val-Pro-Ile-Ala-Gln-Lys-OH trifluoroacetate salt


Product No. Pack Size Available ADS InfoAnalytical Data Sheet List Price Online Order Price
4063291.0001 1 mg Request lead time  
CHF 115.00
CHF 106.95 (7%)


Smac-N7 Peptide corresponds to the N-terminal seven residues of Smac (second mitochondria-derived activator of caspase) also known as DIABLO. Smac/DIABLO is a mitochondrial proapoptotic protein that activates caspases in the cytochrome c/Apaf-1/caspase-9 pathway by neutralizing inhibitor of apoptosis protein (IAP). Smac-N7 peptide promoted procaspase-3 activation in vitro at around 10 µM and inhibited binding of caspase-9-p12 to the BIR3 (baculoviral IAP repeat 3) domain of XIAP (X-linked IAP). The finding that Smac/DIABLO agonists could enhance the apoptosis-inducing potential of irradiation and chemotherapeutic drugs might lead to promising new candidates for cancer treatment.
Catalog Number H-6656
One Letter Code AVPIAQK
Synonyms Mitochondrial Diablo Homolog (1-7) (human, mouse), Second Mitochondria-derived Activator of Caspase (1-7) (human, mouse), Smac Protein (1-7) (human, mouse)
Molecular Formula C₃₃H₅₉N₉O₉
Relative Molecular Mass 725.89
CAS Registry Number 401913-57-3
Source Synthetic
Storage Conditions -20 ± 5 °C