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Details
The protein dermcidin expressed in the sweat glands is secreted into the sweat and transported to the epidermal surface. The concomitant processing of the protein yields a broad-spectrum antimicrobial 47 amino acid peptide, dermcidin-1 (DCD-1).
Dermcidin and naturally occurring fragments as DCD-1L do not perturb membrane permeability and bind to distinct surface molecules. Niyonsaba et al. have reported that DCD-1L stimulates keratinocytes to generate cytokines and chemokines such as TNF-α, IL-8, CXCL10, and CCL20.
Catalog Number
H-7316
One Letter Code
SSLLEKGLDGAKKAVGGLGKLGKDAVEDLESVGKGAVHDVKDVLDSVL
Synonyms
DCD-1L (human)
Molecular Formula
C₂₁₀H₃₅₉N₅₇O₇₁
Relative Molecular Mass
4818.50
CAS Registry Number
478898-18-9
Source
Synthetic
Storage Conditions
-20 ± 5 °C
Keywords
Antimicrobial peptide from human sweat
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