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Potent and selective neuropeptide FF (NPFF) receptor antagonist. RF9 (1-Adamantanecarbonyl-Arg-Phe-NH₂) blocked the delayed and long-lasting paradoxical opioid-induced hyperalgesia and prevented the development of associated tolerance. RF9 could also efficiently block the increase in blood pressure and heart rate evoked by NPFF.
Catalog Number
G-4800
Molecular Formula
C₂₆H₃₈N₆O₃
Relative Molecular Mass
482.63
CAS Registry Number
876310-60-0
Source
Synthetic
Storage Conditions
-20 ± 5 °C
Application
Cardiovascular System & Diseases
Opioid Research
Opioid Research
Links / Documents:
Bachem product citations
Product citations
Erratum: F.Simonin et al.,
Proc. Natl. Acad. Sci. USA,
103,
16058 (2006)