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Details
Apelin-17 is an endogenous ligand of the human orphan G protein-coupled receptor APJ, reported to act as a coreceptor of CD4 for human and simian immunodeficiency viruses. Apelin-17 and apelin-13 represent the predominant molecular forms of apelin present in the whole brain, hypothalamus, and plasma. Like apelin-13, apelin-17 exhibited a high activity on extracellular acidification rate and strongly inhibited forskolin-stimulated cAMP production in CHO cells expressing the human or the rat apelin receptor. The peptide might play a crucial role in the maintenance of body fluid homeostasis by counteracting AVP (arginine vasopressin) actions through inhibition of AVP neuron activity and AVP release.
Catalog Number
H-6302
One Letter Code
KFRRQRPRLSHKGPMPF
Synonyms
Apelin Precursor (61-77) (human, bovine, mouse, rat), Preproapelin (61-77) (human, bovine, mouse, rat)
Molecular Formula
C₉₆H₁₅₆N₃₄O₂₀S
Relative Molecular Mass
2138.58
CAS Registry Number
217082-57-0
Source
Synthetic
Storage Conditions
-20 ± 5 °C
Keywords
Regulator of body fluid homeostasis
Application
Virology
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