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Myelin Basic Protein (85-99) Peptide Antagonist trifluoroacetate salt
H-Glu-Lys-Pro-Lys-Val-Glu-Ala-Tyr-Lys-Ala-Ala-Ala-Ala-Pro-Ala-OH trifluoroacetate salt


Product No. Pack Size Available ADS InfoAnalytical Data Sheet List Price Online Order Price
4049448.0001 1 mg Request lead time  
CHF 315.00
CHF 292.95 (7%)


The antagonistic 15-peptide EKPKVEAYKAAAAPA competes with MBP (85-99), the immunodominant epitope of myelin basic protein (MBP), a major candidate autoantigen in multiple sclerosis (MS), for binding to human leukocyte antigen (HLA)-DR2. The peptide also inhibits IL-2 secretion by MBP (85-99) specific T-cell clones and induces the production of Th2 cytokines by splenocytes. Furthermore, it could be shown that the peptide is able to suppress experimental autoimmune encephalomyelitis (EAE) in several models in a manner that is equipotent to random amino acid copolymers, such as Copaxone [poly (Y,E,A,K)n]. Therefore, this synthetic peptide might be suitable in the studying of MS.
Catalog Number H-6292
Synonyms MBP (85-99) Peptide Antagonist
Molecular Formula C₇₀H₁₁₄N₁₈O₂₁
Relative Molecular Mass 1543.78
CAS Registry Number 444305-16-2
Source Synthetic
Storage Conditions -20 ± 5 °C