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Product No. Pack Size Available ADS InfoAnalytical Data Sheet List Price Online Order Price Qty
4049313.0001 1 mg Ships within 1 business day ADSExemplary Data Sheet of a current available lot.
CHF 315.00
CHF 292.95 (7%)


Specific substrate for cathepsin D (Km = 53 µM, kcat = 7.28 s⁻¹, kcat/Km = 0.14 µM⁻¹s⁻¹) with a single cathepsin cleavage site between the two Phe residues. It is flanked by an N-terminal AMCA-fluorophore (7-amino-4-methylcoumarin-3-acetic acid) and a C-terminal biotin moiety. After enzymatic hydrolysis the biotin-conjugated cleavage product and undigested substrate AMCA-EEKPISFFRLGK(Biotinyl)-amide can be removed with streptavidin-coated magnetic beads. The remaining fluorescent peptide in solution represents the amount of digested substrate. The versatility of this cathepsin D 'digest and pull down assay' is applicable for routine assays.
Catalog Number M-2610
Synonyms (7-Amino-4-methylcoumarin-3-yl)acetyl-Glu-Glu-Lys-Pro-Ile-Ser-Phe-Phe-Arg-Leu-Gly-Lys(biotinyl)-NH₂
Molecular Formula C₉₀H₁₃₁N₂₁O₂₂S
Relative Molecular Mass 1891.22
CAS Registry Number 851231-19-1
Source Synthetic
Storage Conditions -20 ± 5 °C
Keywords Cathepsin D substrate
Application Biotinylated Peptides


Enzyme Substrates Inhibitors
Cathepsin D