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Details
The Italian mutation of β-amyloid 1-40 (E22K) aggregates more rapidly than the wild-type sequence 1-40. It showed increased neurotoxicity, which (according to a solid-phase NMR-study of Masuda et al.) may be due to the salt bridge formed between Lys²² and Asp²³ in the minor conformer. As the Arctic, Flemish, and Dutch mutants, the Italian mutant is degraded considerably more slowly than wild-type Aβ by neprilysin.
Catalog Number
H-6698
APC Number
62-0-91
One Letter Code
DAEFRHDSGYEVHHQKLVFFAKDVGSNKGAIIGLMVGGVV
Synonyms
Amyloid β-Protein (1-40) E22K, Amyloid β-Protein (1-40) Italian Mutation, [Lys22] β-Amyloid (1-40)
Molecular Formula
C₁₉₅H₃₀₀N₅₄O₅₆S
Relative Molecular Mass
4328.92
CAS Registry Number
302905-01-7
Source
Synthetic
Storage Conditions
-20 ± 5 °C
Application
Alzheimer's Disease
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