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Details
2-(2-Furoyl)-PAR-2 (2-6)-Orn amide (mouse, rat) is a potent and selective PAR-2 agonist. In cultured human PAR-2-expressing cells (2-Furoyl)-LIGRLO-amide was equally effective as SLIGRL-amide (H-5078), in rat PAR-2-expressing cells it was 10 to 25 times more potent than SLIGRLamide in increasing intracellular calcium levels. In bioassays of tissue PAR-2 activity, measured as arterial vasodilation and hyperpolarization this agonist was 10 to 300 times more potent than H-5078.
Catalog Number
H-6246
APC Number
85-2-03
Synonyms
(2-Furoyl)-LIGRLOamide, 2-Furoyl-LIGRLO-NH2 Potent and Selective Protease-Activated Receptor 2 (PAR2) Agonist
Molecular Formula
C₃₆H₆₃N₁₁O₈
Relative Molecular Mass
777.97
CAS Registry Number
[729589-58-6] net
Source
Synthetic
Storage Conditions
-20 ± 5 °C
Areas of Interest
Cardiovascular System & Diseases
Hematology
Hematology
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